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Nexium is suggested for the therapy of gastroesophageal reflux illness, duodenal abscess, belly lesions and various other disorders that might have been induced by excessive production of acid in the belly. If you are presently taking tacrolimus, rifampin, methotrexate, voriconazole, diazepam, HIV/AIDS drugs, dexamethasone, citalopram, cilostazol or digoxin, your doctor or pharmacologist should understand about it. Nexium is most reliable when taken an hour before eating, so it's a good suggestion to time it to your meals and take it at the same time each day to stay away from missing out on any one of your routine doses.